据欧盟食品安全局消息，应欧委会的要求，欧盟食品安全局评估了胭脂树籽皮（annatto）提取物作为食品添加剂的安全性。
胭脂树籽皮提取物分为胭脂树橙（bixin）基与降胭脂树橙（norbixin）基。经过毒理学试验，欧盟食品安全局认为，胭脂树橙的ADI设为6 mg /kg体重 /天，降胭脂树橙的ADI设为0.3 mg /kg体重/天 较为合理。
部分原文报道如下：
Following a request from the European Commission to EFSA， the EFSA Panel on Food Additives and Nutrient Sources added to Food （ANS） was asked to re-evaluate the safety of annatto extracts， bixin-based and norbixin-based， when used as a food additive and to evaluate the safety of aqueous-processed bixin （Annatto E）； solvent-extracted bixin （Annatto B）； alkali-processed norbixin， acid-precipitated （Annatto F）； alkali-processed norbixin， not acid-precipitated （Annatto G） and solvent-extracted norbixin （Annatto C） with the view to replac the currently authorised annatto extracts （E 160b）。
